| Title |
Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen
|
|---|---|
| Published in |
Journal of Pain Research, March 2013
|
| DOI | 10.2147/jpr.s42184 |
| Pubmed ID | |
| Authors |
Di Pierro Francesco, Rapacioli Giuliana, Adriana Di Maio Eleonora, Appendino Giovanni, Franceschi Federico, Togni Stefano |
| Abstract |
In addition to its anti-inflammatory activity, Meriva(®), a proprietary lecithin formulation of curcumin, has been anecdotally reported to decrease acute pain in patients with various chronic diseases. Given that curcumin can desensitize transient receptor potential A1, a nociceptor seemingly also mediating the analgesic effect of acetaminophen, as well as inhibiting and downregulating the expression of cyclo-oxygenase 2, the selective target of nimesulide, a nonsteroidal anti-inflammatory agent, we carried out a pilot comparative study of the acute pain-relieving properties of these three agents. At a dose of 2 g (corresponding to 400 mg of curcumin), Meriva showed clear analgesic activity, comparable with that of a standard dose (1 g) of acetaminophen, but lower than that of a therapeutic (100 mg) dose of nimesulide. The analgesic activity of lower (1.5 g) doses of Meriva was less satisfactory, and the onset of activity was longer than that of nimesulide for both doses. On the other hand, gastric tolerability was significantly better than that of nimesulide and comparable with that of acetaminophen. Taken together, our results show that the preclinical analgesic properties of curcumin have clinical relevance, at least at a dose of 2 g as the Meriva formulation. While this dose is significantly higher than that used to relieve chronic inflammatory conditions (1-1.2 g/day), its pain-relieving activity could benefit from the general downregulation of the inflammatory response induced by curcumin, considering that the transient receptor potential channel-mediated mechanisms of analgesia are magnified by attenuation of inflammation. In patients on treatment with Meriva, this would also translate into better control of acute pain, providing a rationale for the analgesic properties associated with this curcumin formulation. |
X Demographics
The data shown below were collected from the profiles of 68 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 32% |
| Canada | 2 | 3% |
| Singapore | 1 | 1% |
| Côte d'Ivoire | 1 | 1% |
| Comoros | 1 | 1% |
| Portugal | 1 | 1% |
| Ireland | 1 | 1% |
| United Kingdom | 1 | 1% |
| Australia | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 37 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 56 | 82% |
| Practitioners (doctors, other healthcare professionals) | 9 | 13% |
| Scientists | 2 | 3% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Italy | 1 | <1% |
| Belgium | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 97 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 16% |
| Student > Bachelor | 16 | 16% |
| Student > Master | 14 | 14% |
| Student > Ph. D. Student | 8 | 8% |
| Other | 7 | 7% |
| Other | 20 | 20% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 29% |
| Agricultural and Biological Sciences | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
| Neuroscience | 8 | 8% |
| Nursing and Health Professions | 7 | 7% |
| Other | 22 | 22% |
| Unknown | 19 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 104. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#414,900
of 25,804,096 outputs
Outputs from Journal of Pain Research
#53
of 2,010 outputs
Outputs of similar age
#2,646
of 207,174 outputs
Outputs of similar age from Journal of Pain Research
#1
of 24 outputs
Altmetric has tracked 25,804,096 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,010 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one has done particularly well, scoring higher than 97% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.