RT @renesugar: Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents #LongCovid #NeuroCovid https://t.co/Q1HPK…

https://t.co/Q1HPKGp9Ou "Finally, in vitro and ex vivo analyses have showed interactions between 5HT and ET1 at physiological concentrations, with the former contributing to vascular growth and contractile responses induced by the latter."

https://t.co/Q1HPKGp9Ou "High plasma 5HT concentration can lead to thrombosis and vasoconstriction in animal models."

https://t.co/Q1HPKGp9Ou "5HT is locally released via serotonin transporter (SERT) by activated platelets, which serve as storage site, & significantly changes the function of both endothelial cells & VSM, inducing smooth muscle cell proliferation

https://t.co/Q1HPKGp9Ou "The monoamine serotonin (5HT) is one of the main vasoconstrictors and exerts its effect through 5HT1B and 5HT2A receptors located on the membrane of VSM cells."

Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents #LongCovid #NeuroCovid https://t.co/Q1HPKGp9Ou "There is also an established relationship between the serotonergic system and endothelium."