| Title |
Bismuth oxide aqueous colloidal nanoparticles inhibit Candida albicans growth and biofilm formation
|
|---|---|
| Published in |
International Journal of Nanomedicine, April 2013
|
| DOI | 10.2147/ijn.s38708 |
| Pubmed ID | |
| Authors |
Rene Hernandez-Delgadillo, Donaji Velasco-Arias, Juan Jose Martinez-Sanmiguel, David Diaz, Inti Zumeta-Dube, Katiushka Arevalo-Niño, Claudio Cabral-Romero |
| Abstract |
Multiresistance among microorganisms to common antimicrobials has become one of the most significant concerns in modern medicine. Nanomaterials are a new alternative to successfully treat the multiresistant microorganisms. Nanostructured materials are used in many fields, including biological sciences and medicine. Recently, it was demonstrated that the bactericidal activity of zero-valent bismuth colloidal nanoparticles inhibited the growth of Streptococcus mutans; however the antimycotic potential of bismuth nanostructured derivatives has not yet been studied. The main objective of this investigation was to analyze the fungicidal activity of bismuth oxide nanoparticles against Candida albicans, and their antibiofilm capabilities. Our results showed that aqueous colloidal bismuth oxide nanoparticles displayed antimicrobial activity against C. albicans growth (reducing colony size by 85%) and a complete inhibition of biofilm formation. These results are better than those obtained with chlorhexidine, nystatin, and terbinafine, the most effective oral antiseptic and commercial antifungal agents. In this work, we also compared the antimycotic activities of bulk bismuth oxide and bismuth nitrate, the precursor metallic salt. These results suggest that bismuth oxide colloidal nanoparticles could be a very interesting candidate as a fungicidal agent to be incorporated into an oral antiseptic. Additionally, we determined the minimum inhibitory concentration for the synthesized aqueous colloidal Bi2O3 nanoparticles. |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 15% |
| Student > Ph. D. Student | 17 | 14% |
| Student > Bachelor | 15 | 12% |
| Researcher | 9 | 7% |
| Student > Doctoral Student | 7 | 6% |
| Other | 23 | 19% |
| Unknown | 34 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 22 | 18% |
| Agricultural and Biological Sciences | 13 | 10% |
| Biochemistry, Genetics and Molecular Biology | 11 | 9% |
| Materials Science | 9 | 7% |
| Medicine and Dentistry | 7 | 6% |
| Other | 25 | 20% |
| Unknown | 37 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2013.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#3,598
of 4,123 outputs
Outputs of similar age
#186,920
of 212,987 outputs
Outputs of similar age from International Journal of Nanomedicine
#53
of 60 outputs
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So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.