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The influence of perivascular adipose tissue on vascular homeostasis

Overview of attention for article published in Vascular Health and Risk Management, March 2013
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Title
The influence of perivascular adipose tissue on vascular homeostasis
Published in
Vascular Health and Risk Management, March 2013
DOI 10.2147/vhrm.s33760
Pubmed ID
Authors

Theodora Szasz, Gisele Facholi Bomfim, R Clinton Webb

Abstract

The perivascular adipose tissue (PVAT) is now recognized as an active contributor to vascular function. Adipocytes and stromal cells contained within PVAT are a source of an ever-growing list of molecules with varied paracrine effects on the underlying smooth muscle and endothelial cells, including adipokines, cytokines, reactive oxygen species, and gaseous compounds. Their secretion is regulated by systemic or local cues and modulates complex processes, including vascular contraction and relaxation, smooth muscle cell proliferation and migration, and vascular inflammation. Recent evidence demonstrates that metabolic and cardiovascular diseases alter the morphological and secretory characteristics of PVAT, with notable consequences. In obesity and diabetes, the expanded PVAT contributes to vascular insulin resistance. PVAT-derived cytokines may influence key steps of atherogenesis. The physiological anticontractile effect of PVAT is severely diminished in hypertension. Above all, a common denominator of the PVAT dysfunction in all these conditions is the immune cell infiltration, which triggers the subsequent inflammation, oxidative stress, and hypoxic processes to promote vascular dysfunction. In this review, we discuss the currently known mechanisms by which the PVAT influences blood vessel function. The important discoveries in the study of PVAT that have been made in recent years need to be further advanced, to identify the mechanisms of the anticontractile effects of PVAT, to explore the vascular-bed and species differences in PVAT function, to understand the regulation of PVAT secretion of mediators, and finally, to uncover ways to ameliorate cardiovascular disease by targeting therapeutic approaches to PVAT.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
Argentina 1 <1%
Portugal 1 <1%
Unknown 142 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 26 18%
Student > Ph. D. Student 24 16%
Researcher 20 14%
Student > Bachelor 18 12%
Professor > Associate Professor 8 5%
Other 26 18%
Unknown 24 16%
Readers by discipline Count As %
Medicine and Dentistry 43 29%
Agricultural and Biological Sciences 25 17%
Biochemistry, Genetics and Molecular Biology 19 13%
Pharmacology, Toxicology and Pharmaceutical Science 14 10%
Immunology and Microbiology 6 4%
Other 9 6%
Unknown 30 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2013.
All research outputs
#20,823,121
of 25,584,565 outputs
Outputs from Vascular Health and Risk Management
#663
of 785 outputs
Outputs of similar age
#159,453
of 206,591 outputs
Outputs of similar age from Vascular Health and Risk Management
#7
of 7 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 785 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,591 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.