Title |
Monte Carlo simulations guided by imaging to predict the in vitro ranking of radiosensitizing nanoparticles
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Published in |
International Journal of Nanomedicine, November 2016
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DOI | 10.2147/ijn.s111320 |
Pubmed ID | |
Authors |
Paul Retif, Aurélie Reinhard, Héna Paquot, Valérie Jouan-Hureaux, Alicia Chateau, Lucie Sancey, Muriel Barberi-Heyob, Sophie Pinel, Thierry Bastogne |
Abstract |
This article addresses the in silico-in vitro prediction issue of organometallic nanoparticles (NPs)-based radiosensitization enhancement. The goal was to carry out computational experiments to quickly identify efficient nanostructures and then to preferentially select the most promising ones for the subsequent in vivo studies. To this aim, this interdisciplinary article introduces a new theoretical Monte Carlo computational ranking method and tests it using 3 different organometallic NPs in terms of size and composition. While the ranking predicted in a classical theoretical scenario did not fit the reference results at all, in contrast, we showed for the first time how our accelerated in silico virtual screening method, based on basic in vitro experimental data (which takes into account the NPs cell biodistribution), was able to predict a relevant ranking in accordance with in vitro clonogenic efficiency. This corroborates the pertinence of such a prior ranking method that could speed up the preclinical development of NPs in radiation therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 23% |
Researcher | 3 | 10% |
Student > Bachelor | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 16% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 19% |
Physics and Astronomy | 5 | 16% |
Chemistry | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 4 | 13% |
Unknown | 10 | 32% |