Title |
Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery
|
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Published in |
Journal of Pain Research, November 2016
|
DOI | 10.2147/jpr.s111733 |
Pubmed ID | |
Authors |
Bruce Parsons, Qijiang Zhu, Li Xie, Chunming Li, Raymond Cheung |
Abstract |
To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery. This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery. Pain scores were reduced in the PAR/VAL group (n=98), relative to placebo (n=97), on Day 2 (-21%, P<0.001) and Day 3 (-23%, P=0.004). Pain interference with function scores were also significantly lower in the PAR/VAL group, compared with placebo, on Day 2 (-29%, P<0.001) and Day 3 (-28%, P=0.013). Consumption of supplemental morphine was significantly lower in the PAR/VAL group relative to placebo at 24 hours (-37%, P=0.010) and trended lower at 48 (-28%) and 72 hours (-26%). Patients in the PAR/VAL group also had a reduced risk of experiencing specific opioid-related symptoms, including "inability to concentrate" (relative risk =0.53) and "nausea" (relative risk =0.60) on Day 2. Both Patient and Physician Global Evaluation of Study Medication scores were better in the PAR/VAL group than in the placebo group. The current study adds support for the use of parecoxib in patients following major gynecologic surgery. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 16% |
Student > Bachelor | 3 | 16% |
Student > Ph. D. Student | 2 | 11% |
Researcher | 2 | 11% |
Student > Postgraduate | 2 | 11% |
Other | 6 | 32% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 63% |
Psychology | 2 | 11% |
Nursing and Health Professions | 1 | 5% |
Unspecified | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Other | 1 | 5% |
Unknown | 1 | 5% |