Type 1 insulin-like growth factor receptor monoclonal antibody (HX-1162) treatment for liver cancer
OncoTargets and therapy, May 2013
One of the most important molecules mediating the proliferation, growth, and metastasis of cancer cells is insulin-like growth factor (IGF), with its receptor IGF-1R. Here, we describe the potential of an IGF-1R monoclonal antibody, HX-1162, on liver cancer apoptosis in vitro and in vivo. We found that HX-1162 could induce the apoptosis of cultured liver cancer cells. Additionally, HX-1162 treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. We conclude that IGF-1R targeting therapy provides a new avenue toward treating liver cancer.
|Members of the public||5||100%|
|Readers by professional status||Count||As %|
|Readers by discipline||Count||As %|
|Agricultural and Biological Sciences||1||100%|