| Title |
Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs
|
|---|---|
| Published in |
International Journal of Nanomedicine, April 2013
|
| DOI | 10.2147/ijn.s42511 |
| Pubmed ID | |
| Authors |
Baharak Bahmani, Christian Y Lytle, Ameae M Walker, Sharad Gupta, Valentine I Vullev, Bahman Anvari |
| Abstract |
Near-infrared nanoconstructs present a potentially effective platform for site-specific and deep tissue optical imaging and phototherapy. We have engineered a polymeric nanocapsule composed of polyallylamine hydrochloride (PAH) chains cross-linked with sodium phosphate and doped with indocyanine green (ICG) toward such endeavors. The ICG-doped nanocapsules were coated covalently with polyethylene glycol (5000 daltons) through reductive amination. We administrated the constructs by tail vein injection to healthy mice. To characterize the biodistribution of the constructs, we performed in vivo quantitative fluorescence imaging and subsequently analyzed the various extracted organs. Our results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time of ICG and delay its hepatic accumulation. Increased bioavailability of ICG, due to encapsulation, offers the potential of extending the clinical applications of ICG, which are currently limited due to rapid elimination of ICG from the vasculature. Our results also indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 1 | 2% |
| Denmark | 1 | 2% |
| Unknown | 52 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 20% |
| Student > Master | 9 | 17% |
| Researcher | 6 | 11% |
| Professor > Associate Professor | 6 | 11% |
| Student > Bachelor | 4 | 7% |
| Other | 13 | 24% |
| Unknown | 5 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 7 | 13% |
| Agricultural and Biological Sciences | 6 | 11% |
| Chemistry | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 11% |
| Physics and Astronomy | 4 | 7% |
| Other | 18 | 33% |
| Unknown | 7 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2013.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#3,598
of 4,123 outputs
Outputs of similar age
#186,924
of 212,995 outputs
Outputs of similar age from International Journal of Nanomedicine
#53
of 60 outputs
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So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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