| Title |
Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, May 2013
|
| DOI | 10.2147/ndt.s43137 |
| Pubmed ID | |
| Authors |
Ryo Fujiki, Kiichiro Morita, Mamoru Sato, Yuji Kamada, Yusuke Kato, Masayuki Inoue, Yoshihisa Shoji, Naohisa Uchimura |
| Abstract |
Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Norway | 1 | 2% |
| Unknown | 40 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 17% |
| Student > Doctoral Student | 5 | 12% |
| Researcher | 4 | 10% |
| Student > Bachelor | 4 | 10% |
| Professor | 3 | 7% |
| Other | 10 | 24% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 26% |
| Psychology | 10 | 24% |
| Neuroscience | 2 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Sports and Recreations | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 14 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2013.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,584
of 3,132 outputs
Outputs of similar age
#178,806
of 204,330 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#44
of 53 outputs
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