Title |
Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook
|
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Published in |
International Journal of Nanomedicine, December 2016
|
DOI | 10.2147/ijn.s117495 |
Pubmed ID | |
Authors |
Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu |
Abstract |
With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances on the application of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled release systems that are able to respond to intracellular environmental changes, such as pH, ATP, GSH, enzyme, glucose, and H2O2. Moreover, drug delivery induced by exogenous stimuli including temperature, light, magnetic field, ultrasound, and electricity is also summarized. These advanced technologies demonstrate current challenges, and provide a bright future for precision diagnosis and treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 255 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 49 | 19% |
Student > Ph. D. Student | 42 | 16% |
Researcher | 25 | 10% |
Student > Bachelor | 21 | 8% |
Student > Doctoral Student | 11 | 4% |
Other | 32 | 13% |
Unknown | 75 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 34 | 13% |
Biochemistry, Genetics and Molecular Biology | 25 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 9% |
Engineering | 19 | 7% |
Agricultural and Biological Sciences | 17 | 7% |
Other | 46 | 18% |
Unknown | 91 | 36% |