Title |
Novel small molecule EGFR inhibitors as candidate drugs in non-small cell lung cancer
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Published in |
OncoTargets and therapy, May 2013
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DOI | 10.2147/ott.s28155 |
Pubmed ID | |
Authors |
Rossana Berardi, Matteo Santoni, Francesca Morgese, Zelmira Ballatore, Agnese Savini, Azzurra Onofri, Paola Mazzanti, Mirco Pistelli, Chiara Pierantoni, Mariagrazia De Lisa, Miriam Caramanti, Silvia Pagliaretta, Chiara Pellei, Stefano Cascinu |
Abstract |
In the last decade, better understanding of the role of epidermal growth factor receptor in the pathogenesis and progression of non-small cell lung cancer has led to a revolution in the work-up of these neoplasms. Tyrosine kinase inhibitors, such as erlotinib and gefitinib, have been approved for the treatment of non-small cell lung cancer, demonstrating an improvement in progression-free and overall survival, particularly in patients harboring activating EGFR mutations. Nevertheless, despite initial responses and long-lasting remissions, resistance to tyrosine kinase inhibitors invariably develops, most commonly due to the emergence of secondary T790M mutations or to the amplification of mesenchymal-epithelial transition factor (c-Met), which inevitably leads to treatment failure. Several clinical studies are ongoing (http://www.clinicaltrials.gov), aimed to evaluate the efficacy and toxicity of combined approaches and to develop novel irreversible or multitargeted tyrosine kinase inhibitors and mutant-selective inhibitors to overcome such resistance. This review is an overview of ongoing Phase I, II, and III trials of novel small molecule epidermal growth factor receptor inhibitors and combinations in non-small cell lung cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
Germany | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 15% |
Researcher | 5 | 13% |
Other | 4 | 10% |
Student > Master | 4 | 10% |
Student > Bachelor | 4 | 10% |
Other | 12 | 30% |
Unknown | 5 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 25% |
Biochemistry, Genetics and Molecular Biology | 5 | 13% |
Chemistry | 5 | 13% |
Agricultural and Biological Sciences | 5 | 13% |
Nursing and Health Professions | 3 | 8% |
Other | 6 | 15% |
Unknown | 6 | 15% |