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Nanobubbles for enhanced ultrasound imaging of tumors

Overview of attention for article published in International Journal of Nanomedicine, February 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

patent
1 patent
peer_reviews
1 peer review site
facebook
1 Facebook page

Citations

dimensions_citation
192 Dimensions

Readers on

mendeley
143 Mendeley
Title
Nanobubbles for enhanced ultrasound imaging of tumors
Published in
International Journal of Nanomedicine, February 2012
DOI 10.2147/ijn.s28830
Pubmed ID
Authors

Rongqin Zheng, Tinghui Yin, Ping Wang, Rongqin Zheng, Bowen Zheng, Du Cheng, Xinling Zhang, Xin-Tao Shuai

Abstract

The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow for targeted imaging and therapy. However, the nanoscale size of the particles used has the disadvantage of weakening the imaging ability of clinical diagnostic ultrasound. In this work, we fabricated a lipid NBs contrast-enhanced ultrasound agent and evaluated its passive targeting ability in vivo. The results showed that the NBs were small (436.8 ± 5.7 nm), and in vitro ultrasound imaging suggested that the ultrasonic imaging ability is comparable to that of microbubbles (MBs). In vivo experiments confirmed the ability of NBs to passively target tumor tissues. The NBs remained in the tumor area for a longer period because they exhibited enhanced permeability and retention. Direct evidence was obtained by direct observation of red fluorescence-dyed NBs in tumor tissue using confocal laser scanning microscopy. We have demonstrated the ability to fabricate NBs that can be used for the in vivo contrast-enhanced imaging of tumor tissue and that have potential for drug/gene delivery.

Mendeley readers

The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Germany 1 <1%
Unknown 141 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 42 29%
Student > Master 18 13%
Student > Bachelor 18 13%
Researcher 13 9%
Student > Doctoral Student 10 7%
Other 14 10%
Unknown 28 20%
Readers by discipline Count As %
Engineering 47 33%
Medicine and Dentistry 13 9%
Chemistry 10 7%
Biochemistry, Genetics and Molecular Biology 8 6%
Agricultural and Biological Sciences 7 5%
Other 24 17%
Unknown 34 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2020.
All research outputs
#5,384,587
of 19,629,044 outputs
Outputs from International Journal of Nanomedicine
#507
of 3,420 outputs
Outputs of similar age
#45,268
of 171,219 outputs
Outputs of similar age from International Journal of Nanomedicine
#17
of 65 outputs
Altmetric has tracked 19,629,044 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,420 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,219 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.