| Title |
Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, December 2016
|
| DOI | 10.2147/ndt.s123338 |
| Pubmed ID | |
| Authors |
Soo Hyun Joo, Chang Uk Lee, Hyun Kook Lim |
| Abstract |
Although several prior works reported that apathy is associated with conversion to Alzheimer's disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects. Fifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects. We observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group. Our findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 17% |
| Professor > Associate Professor | 5 | 12% |
| Student > Doctoral Student | 4 | 10% |
| Researcher | 4 | 10% |
| Student > Bachelor | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 14 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 24% |
| Psychology | 6 | 14% |
| Medicine and Dentistry | 6 | 14% |
| Unspecified | 1 | 2% |
| Social Sciences | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 15 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
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#3,415,054
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Outputs from Neuropsychiatric Disease and Treatment
#493
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Outputs of similar age
#62,665
of 416,449 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#11
of 54 outputs
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