| Title |
Bottom-up fabrication of zwitterionic polymer brushes on intraocular lens for improved biocompatibility
|
|---|---|
| Published in |
International Journal of Nanomedicine, December 2016
|
| DOI | 10.2147/ijn.s107491 |
| Pubmed ID | |
| Authors |
Yuemei Han, Xu Xu, Junmei Tang, Chenghui Shen, Quankui Lin, Hao Chen |
| Abstract |
Intraocular lens (IOL) is an efficient implantable device commonly used for treating cataracts. However, bioadhesion of bacteria or residual lens epithelial cells on the IOL surface after surgery causes postoperative complications, such as endophthalmitis or posterior capsular opacification, and leads to loss of sight again. In the present study, zwitterionic polymer brushes were fabricated on the IOL surface via bottom-up grafting procedure. The attenuated total reflection-Fourier transform infrared and contact angle measurements indicated successful surface modification, as well as excellent hydrophilicity. The coating of hydrophilic zwitterionic polymer effectively decreased the bioadhesion of lens epithelial cells or bacteria. In vivo intraocular implantation results showed good in vivo biocompatibility of zwitterionic IOL and its effectiveness against postoperative complications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 26% |
| Student > Master | 4 | 17% |
| Researcher | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Unspecified | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 6 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 4 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Engineering | 3 | 13% |
| Materials Science | 3 | 13% |
| Medicine and Dentistry | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 7 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2017.
All research outputs
#20,110,957
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#2,965
of 4,077 outputs
Outputs of similar age
#299,126
of 417,676 outputs
Outputs of similar age from International Journal of Nanomedicine
#55
of 73 outputs
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