| Title |
Efficacy of L-carnitine supplementation on frailty status and its biomarkers, nutritional status, and physical and cognitive function among prefrail older adults: a double-blind, randomized, placebo-controlled clinical trial
|
|---|---|
| Published in |
Clinical Interventions in Aging, November 2016
|
| DOI | 10.2147/cia.s113287 |
| Pubmed ID | |
| Authors |
M Badrasawi, Suzana Shahar, AM Zahara, R Nor Fadilah, Devinder Kaur Ajit Singh |
| Abstract |
Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency, including L-carnitine, has been proposed to be associated with its pathophysiology. Nevertheless, the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus, this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function, cognition, and nutritional status among prefrail older adults in Klang Valley, Malaysia. This study is a randomized, double-blind, placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit, selected frailty biomarkers (interleukin-6, tumor necrosis factor-alpha, and insulin-like growth factor-1), physical function, cognitive function, nutritional status and biochemical profile. The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P<0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria, four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Poland | 1 | <1% |
| Unknown | 199 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 14% |
| Student > Bachelor | 25 | 13% |
| Other | 17 | 9% |
| Researcher | 17 | 9% |
| Student > Ph. D. Student | 16 | 8% |
| Other | 31 | 16% |
| Unknown | 66 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 19% |
| Nursing and Health Professions | 23 | 12% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Sports and Recreations | 9 | 5% |
| Agricultural and Biological Sciences | 7 | 4% |
| Other | 34 | 17% |
| Unknown | 76 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2018.
All research outputs
#16,048,009
of 25,374,647 outputs
Outputs from Clinical Interventions in Aging
#1,109
of 1,968 outputs
Outputs of similar age
#186,514
of 317,808 outputs
Outputs of similar age from Clinical Interventions in Aging
#27
of 44 outputs
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