| Title |
Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study
|
|---|---|
| Published in |
Degenerative Neurological and Neuromuscular Disease, January 2017
|
| DOI | 10.2147/dnnd.s116949 |
| Pubmed ID | |
| Authors |
Amanda K Irish, Constance M Erickson, Terry L Wahls, Linda G Snetselaar, Warren G Darling |
| Abstract |
A Paleolithic diet may improve fatigue and quality of life in progressive multiple sclerosis (MS) patients, but past research has evaluated the effects of this dietary intervention in combination with other treatments such as exercise. Thus, the purpose of this pilot study was to evaluate a modified Paleolithic dietary intervention (MPDI) in the treatment of fatigue and other symptoms in relapsing-remitting MS (RRMS). We measured the effects of a MPDI in 17 individuals with RRMS. Of 34 subjects randomly assigned to control (maintain usual diet) and intervention (MPDI) groups, nine subjects (one man) completed the control group and eight subjects (one man) completed the MPDI. Significant improvements were seen in Fatigue Severity Scale score and also in Multiple Sclerosis Quality of Life-54 and time to complete (dominant hand) 9-Hole Peg Test from baseline in MPDI subjects compared to controls. Increased vitamin K serum levels were also observed in MPDI subjects postprotocol compared to controls. A Paleolithic diet may be useful in the treatment and management of MS, by reducing perceived fatigue, increasing mental and physical quality of life, increasing exercise capacity, and improving hand and leg function. By increasing vitamin K serum levels, the MPDI may also reduce inflammation. |
X Demographics
The data shown below were collected from the profiles of 57 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 14 | 25% |
| United Kingdom | 6 | 11% |
| Canada | 2 | 4% |
| Saudi Arabia | 2 | 4% |
| Ireland | 2 | 4% |
| Paraguay | 1 | 2% |
| Mexico | 1 | 2% |
| New Zealand | 1 | 2% |
| Austria | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 26 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 44 | 77% |
| Practitioners (doctors, other healthcare professionals) | 10 | 18% |
| Scientists | 2 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 134 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 18% |
| Student > Master | 16 | 12% |
| Researcher | 11 | 8% |
| Student > Ph. D. Student | 11 | 8% |
| Student > Doctoral Student | 9 | 7% |
| Other | 19 | 14% |
| Unknown | 44 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 20% |
| Nursing and Health Professions | 25 | 19% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Agricultural and Biological Sciences | 5 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 14 | 10% |
| Unknown | 47 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 122. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2023.
All research outputs
#344,484
of 25,584,565 outputs
Outputs from Degenerative Neurological and Neuromuscular Disease
#3
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Outputs of similar age
#7,193
of 422,901 outputs
Outputs of similar age from Degenerative Neurological and Neuromuscular Disease
#1
of 3 outputs
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