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Neuroleptic malignant syndrome: an easily overlooked neurologic emergency

Overview of attention for article published in Neuropsychiatric Disease and Treatment, January 2017
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Mentioned by

twitter
3 tweeters

Citations

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36 Dimensions

Readers on

mendeley
132 Mendeley
Title
Neuroleptic malignant syndrome: an easily overlooked neurologic emergency
Published in
Neuropsychiatric Disease and Treatment, January 2017
DOI 10.2147/ndt.s118438
Pubmed ID
Authors

Ramadhan Oruch, Ian Pryme, Bernt Engelsen, Anders Lund

Abstract

Neuroleptic malignant syndrome is an unpredictable iatrogenic neurologic emergency condition, mainly arising as an idiosyncratic reaction to antipsychotic agent use. It is characterized by distinctive clinical features including a change in mental status, generalized rigidity, hyperpyrexia, and dysautonomia. It can be lethal if not diagnosed and treated properly. Mortality and morbidity attributed to this syndrome have recently declined markedly due to greater awareness, earlier diagnosis, and intensive care intervention. In most cases, the syndrome occurs as a result of a rapid increase in a dose of neuroleptic, especially one of the long-acting ones. Pathophysiology behind this syndrome is attributed to a dopamine receptor blockade inside the neurons rendered by the offending drug and excessive calcium release from the sarcoplasmic reticulum of skeletal myocytes. Laboratory tests, although not diagnostic, may assist in assessing the severity of the syndrome and also the consequent complications. The syndrome has been described in all age groups and occurs more in males than in females. Genetics appears to be central regarding the etiology of the syndrome. Stopping the use of the offending agent, cold intravenous fluids, and removal of the causative agent and its possible active metabolites is the cornerstone of treatment. Periodic observation of psychotic patients recently started on antipsychotic medications, especially those being treated with depot preparations, may aid to an early diagnosis of the syndrome and lead to early treatment.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 132 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 18 14%
Student > Bachelor 18 14%
Student > Master 15 11%
Other 14 11%
Researcher 7 5%
Other 23 17%
Unknown 37 28%
Readers by discipline Count As %
Medicine and Dentistry 65 49%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Nursing and Health Professions 6 5%
Neuroscience 4 3%
Biochemistry, Genetics and Molecular Biology 4 3%
Other 7 5%
Unknown 38 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2021.
All research outputs
#10,755,178
of 17,904,439 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,294
of 2,699 outputs
Outputs of similar age
#184,853
of 367,746 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#34
of 69 outputs
Altmetric has tracked 17,904,439 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,699 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,746 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.