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Dove Medical Press

Lung-targeting drug delivery system of baicalin-loaded nanoliposomes: development, biodistribution in rabbits, and pharmacodynamics in nude mice bearing orthotopic human lung cancer

Overview of attention for article published in International Journal of Nanomedicine, December 2016
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Title
Lung-targeting drug delivery system of baicalin-loaded nanoliposomes: development, biodistribution in rabbits, and pharmacodynamics in nude mice bearing orthotopic human lung cancer
Published in
International Journal of Nanomedicine, December 2016
DOI 10.2147/ijn.s119895
Pubmed ID
Authors

Yumeng Wei, Jing Liang, Xiaoli Zheng, Chao Pi, Hao Liu, Hongru Yang, Yonggen Zou, Yun Ye, Ling Zhao

Abstract

The present study aims to develop a kind of novel nanoliposomes for the lung-targeting delivery system of baicalin as a Chinese medicine monomer. Baicalin-loaded nanoliposomes were prepared by the effervescent dispersion and lyophilized techniques. Baicalin-loaded nanoliposomes had an average particle size of 131.7±11.7 nm with 0.19±0.02 polydispersity index, 82.8%±1.24% entrapment efficiency and 90.47%±0.93% of yield and sustaining drug release effect over 24 h and were stable for 12 months at least. In vitro no hemolytic activity was observed for the experimental drug concentration. After intravenous administration of baicalin-loaded nanoliposomes to rabbits, drug concentration in the lungs was the highest among the tested organs at all time points and was significantly higher than that of its solution. For the targeting parameters, the relative intake rate and the ratio of peak concentration of lung were 4.837 and 2.789, respectively. Compared with plasma, liver, spleen, and kidney, the ratios of targeting efficacy (Te)liposomes to (Te)injection of lung were increased by a factor of 14.131, 1.893, 3.357, and 3.470, respectively. Furthermore, the results showed that the baicalin-loaded nanoliposomes did not induce lung injury. Importantly, baicalin-loaded nanoliposomes showed better antitumor therapeutic efficacy in the nude mice bearing orthotopic human lung cancer with the median survival time of blank liposomes (11.40±0.16 days), baicalin solution (17.30±0.47 days), and baicalin-loaded nanoliposomes (25.90±0.53 days). Therefore, the liposome is a promising drug carrier with an excellent lung-targeting property and therapeutic effect for the treatment of lung disease, such as lung cancer.

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Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 15%
Student > Bachelor 3 9%
Professor 3 9%
Researcher 3 9%
Student > Doctoral Student 2 6%
Other 5 15%
Unknown 13 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 21%
Biochemistry, Genetics and Molecular Biology 4 12%
Medicine and Dentistry 3 9%
Chemistry 2 6%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 16 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2017.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#3,127
of 4,123 outputs
Outputs of similar age
#313,396
of 416,453 outputs
Outputs of similar age from International Journal of Nanomedicine
#59
of 75 outputs
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