| Title |
Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
|
|---|---|
| Published in |
International Journal of Nanomedicine, June 2013
|
| DOI | 10.2147/ijn.s37140 |
| Pubmed ID | |
| Authors |
Robert Martin, Li, Gobin, Dryden, Kang, Xiao, Li, Zhang |
| Abstract |
Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| United States | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 35 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 24% |
| Researcher | 7 | 18% |
| Student > Postgraduate | 5 | 13% |
| Student > Ph. D. Student | 5 | 13% |
| Student > Doctoral Student | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 2 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 18% |
| Engineering | 6 | 16% |
| Medicine and Dentistry | 6 | 16% |
| Materials Science | 5 | 13% |
| Agricultural and Biological Sciences | 2 | 5% |
| Other | 7 | 18% |
| Unknown | 5 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#14,629,103
of 24,932,434 outputs
Outputs from International Journal of Nanomedicine
#1,545
of 4,056 outputs
Outputs of similar age
#105,151
of 198,969 outputs
Outputs of similar age from International Journal of Nanomedicine
#24
of 65 outputs
Altmetric has tracked 24,932,434 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,056 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,969 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.