Title |
Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma
|
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Published in |
International Journal of Nanomedicine, June 2013
|
DOI | 10.2147/ijn.s37140 |
Pubmed ID | |
Authors |
Robert Martin, Li, Gobin, Dryden, Kang, Xiao, Li, Zhang |
Abstract |
Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 5 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 3% |
United States | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 35 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 24% |
Researcher | 7 | 18% |
Student > Postgraduate | 5 | 13% |
Student > Ph. D. Student | 5 | 13% |
Student > Doctoral Student | 3 | 8% |
Other | 7 | 18% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 7 | 18% |
Engineering | 6 | 16% |
Medicine and Dentistry | 6 | 16% |
Materials Science | 5 | 13% |
Agricultural and Biological Sciences | 2 | 5% |
Other | 7 | 18% |
Unknown | 5 | 13% |