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Temporal changes in serum creatine kinase concentration and degree of muscle rigidity in 24 patients with neuroleptic malignant syndrome

Overview of attention for article published in Neuropsychiatric Disease and Treatment, June 2013
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  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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3 X users
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2 Facebook pages

Citations

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11 Dimensions

Readers on

mendeley
25 Mendeley
Title
Temporal changes in serum creatine kinase concentration and degree of muscle rigidity in 24 patients with neuroleptic malignant syndrome
Published in
Neuropsychiatric Disease and Treatment, June 2013
DOI 10.2147/ndt.s45084
Pubmed ID
Authors

Koichi Nisijima, Katutoshi Shioda

Abstract

Neuroleptic malignant syndrome (NMS) is a dangerous adverse response to antipsychotic drugs. It is characterized by the four major clinical symptoms of hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK) elevation occurs in over 90% of NMS cases. In the present study, the detailed temporal changes in serum CK and degree of muscle rigidity, and the relationship between CK concentration and degree of muscle rigidity over the time course from fever onset, were evaluated in 24 affected patients. The results showed that serum CK peaked on day 2 after onset of fever and returned to within normal limits at day 12. Mild muscle rigidity was observed before the onset of fever in 17 of 24 cases (71%). Muscle rigidity was gradually exacerbated and worsened until day 4 after onset of fever. These findings confirm physicians' empirical understanding of serum CK concentrations and muscle rigidity in NMS based on data accumulated from numerous patients with the syndrome, and they indicate that serum CK may contribute to the early detection of NMS.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 12%
Other 2 8%
Student > Ph. D. Student 2 8%
Student > Postgraduate 2 8%
Researcher 2 8%
Other 3 12%
Unknown 11 44%
Readers by discipline Count As %
Medicine and Dentistry 6 24%
Psychology 2 8%
Unspecified 1 4%
Nursing and Health Professions 1 4%
Neuroscience 1 4%
Other 1 4%
Unknown 13 52%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2013.
All research outputs
#15,740,207
of 25,374,917 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,506
of 3,132 outputs
Outputs of similar age
#116,668
of 206,480 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#21
of 54 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,480 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.