| Title |
A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, January 2017
|
| DOI | 10.2147/ndt.s123612 |
| Pubmed ID | |
| Authors |
Arthur Ernst van Woerkom |
| Abstract |
It is proposed that lithium's therapeutic effects occur indirectly by augmenting a cascade of protective "fail-safe" pathways pre-configured to activate in response to a dangerous low cell [Mg(++)] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg(++)] level. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 36% |
| United Kingdom | 2 | 18% |
| Japan | 1 | 9% |
| Unknown | 4 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 6 | 55% |
| Members of the public | 3 | 27% |
| Scientists | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 8 | 22% |
| Student > Bachelor | 6 | 17% |
| Researcher | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Postgraduate | 2 | 6% |
| Other | 7 | 19% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Agricultural and Biological Sciences | 4 | 11% |
| Neuroscience | 3 | 8% |
| Unspecified | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 9 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2019.
All research outputs
#2,340,386
of 25,584,565 outputs
Outputs from Neuropsychiatric Disease and Treatment
#289
of 3,120 outputs
Outputs of similar age
#45,518
of 422,901 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#5
of 64 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,120 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 422,901 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.