Title |
Tunable and noncytotoxic PET/SPECT-MRI multimodality imaging probes using colloidally stable ligand-free superparamagnetic iron oxide nanoparticles
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Published in |
International Journal of Nanomedicine, January 2017
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DOI | 10.2147/ijn.s127171 |
Pubmed ID | |
Authors |
TH Nguyen Pham, Nigel A Lengkeek, Ivan Greguric, Byung J Kim, Paul A Pellegrini, Stephanie A Bickley, Marcel R Tanudji, Stephen K Jones, Brian S Hawkett, Binh TT Pham |
Abstract |
Physiologically stable multimodality imaging probes for positron emission tomography/single-photon emission computed tomography (PET/SPECT)-magnetic resonance imaging (MRI) were synthesized using the superparamagnetic maghemite iron oxide (γ-Fe2O3) nanoparticles (SPIONs). The SPIONs were sterically stabilized with a finely tuned mixture of diblock copolymers with either methoxypolyethylene glycol (MPEG) or primary amine NH2 end groups. The radioisotope for PET or SPECT imaging was incorporated with the SPIONs at high temperature. (57)Co(2+) ions with a long half-life of 270.9 days were used as a model for the radiotracer to study the kinetics of radiolabeling, characterization, and the stability of the radiolabeled SPIONs. Radioactive (67)Ga(3+) and Cu(2+)-labeled SPIONs were also produced successfully using the optimized conditions from the (57)Co(2+)-labeling process. No free radioisotopes were detected in the aqueous phase for the radiolabeled SPIONs 1 week after dispersion in phosphate-buffered saline (PBS). All labeled SPIONs were not only well dispersed and stable under physiological conditions but also noncytotoxic in vitro. The ability to design and produce physiologically stable radiolabeled magnetic nanoparticles with a finely controlled number of functionalizable end groups on the SPIONs enables the generation of a desirable and biologically compatible multimodality PET/SPECT-MRI agent on a single T2 contrast MRI probe. |
X Demographics
Geographical breakdown
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Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 24% |
Researcher | 8 | 18% |
Student > Bachelor | 5 | 11% |
Student > Master | 4 | 9% |
Professor | 2 | 4% |
Other | 4 | 9% |
Unknown | 11 | 24% |
Readers by discipline | Count | As % |
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Chemistry | 13 | 29% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Engineering | 2 | 4% |
Other | 5 | 11% |
Unknown | 17 | 38% |