| Title |
Cerebral malaria: insight into pathogenesis, complications and molecular biomarkers
|
|---|---|
| Published in |
Infection and Drug Resistance, February 2017
|
| DOI | 10.2147/idr.s125436 |
| Pubmed ID | |
| Authors |
Farah Hafiz Yusuf, Muhammad Yusuf Hafiz, Maria Shoaib, Syed Ahsanuddin Ahmed |
| Abstract |
Cerebral malaria is a medical emergency. All patients with Plasmodium falciparum malaria with neurologic manifestations of any degree should be urgently treated as cases of cerebral malaria. Pathogenesis of cerebral malaria is due to damaged vascular endothelium by parasite sequestration, inflammatory cytokine production and vascular leakage, which result in brain hypoxia, as indicated by increased lactate and alanine concentrations. The levels of the biomarkers' histidine-rich protein II, angiopoietin-Tie-2 system and plasma osteoprotegrin serve as diagnostic and prognostic markers. Brain imaging may show neuropathology around the caudate and putamen. Mortality is high and patients who survive sustain brain injury which manifests as long-term neurocognitive impairments. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 22 | 16% |
| Student > Master | 13 | 10% |
| Researcher | 11 | 8% |
| Student > Ph. D. Student | 11 | 8% |
| Student > Postgraduate | 9 | 7% |
| Other | 24 | 18% |
| Unknown | 46 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 26% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Immunology and Microbiology | 10 | 7% |
| Agricultural and Biological Sciences | 6 | 4% |
| Neuroscience | 3 | 2% |
| Other | 17 | 13% |
| Unknown | 51 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2017.
All research outputs
#20,110,957
of 25,584,565 outputs
Outputs from Infection and Drug Resistance
#1,156
of 2,048 outputs
Outputs of similar age
#308,269
of 426,137 outputs
Outputs of similar age from Infection and Drug Resistance
#4
of 9 outputs
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So far Altmetric has tracked 2,048 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.