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Dove Medical Press

Organelle targeting: third level of drug targeting

Overview of attention for article published in Drug Design, Development and Therapy, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

blogs
1 blog
twitter
1 X user
patent
2 patents

Citations

dimensions_citation
267 Dimensions

Readers on

mendeley
316 Mendeley
Title
Organelle targeting: third level of drug targeting
Published in
Drug Design, Development and Therapy, July 2013
DOI 10.2147/dddt.s45614
Pubmed ID
Authors

Niraj M Sakhrani, Harish Padh

Abstract

Drug discovery and drug delivery are two main aspects for treatment of a variety of disorders. However, the real bottleneck associated with systemic drug administration is the lack of target-specific affinity toward a pathological site, resulting in systemic toxicity and innumerable other side effects as well as higher dosage requirement for efficacy. An attractive strategy to increase the therapeutic index of a drug is to specifically deliver the therapeutic molecule in its active form, not only into target tissue, nor even to target cells, but more importantly, into the targeted organelle, ie, to its intracellular therapeutic active site. This would ensure improved efficacy and minimize toxicity. Cancer chemotherapy today faces the major challenge of delivering chemotherapeutic drugs exclusively to tumor cells, while sparing normal proliferating cells. Nanoparticles play a crucial role by acting as a vehicle for delivery of drugs to target sites inside tumor cells. In this review, we spotlight active and passive targeting, followed by discussion of the importance of targeting to specific cell organelles and the potential role of cell-penetrating peptides. Finally, the discussion will address the strategies for drug/DNA targeting to lysosomes, mitochondria, nuclei and Golgi/endoplasmic reticulum.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 316 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Poland 2 <1%
Russia 2 <1%
Korea, Republic of 1 <1%
Netherlands 1 <1%
Sweden 1 <1%
Iran, Islamic Republic of 1 <1%
Unknown 305 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 76 24%
Researcher 54 17%
Student > Master 46 15%
Student > Bachelor 22 7%
Professor > Associate Professor 19 6%
Other 45 14%
Unknown 54 17%
Readers by discipline Count As %
Chemistry 73 23%
Agricultural and Biological Sciences 43 14%
Biochemistry, Genetics and Molecular Biology 41 13%
Pharmacology, Toxicology and Pharmaceutical Science 29 9%
Medicine and Dentistry 20 6%
Other 42 13%
Unknown 68 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#3,202,100
of 25,373,627 outputs
Outputs from Drug Design, Development and Therapy
#178
of 2,268 outputs
Outputs of similar age
#26,449
of 206,704 outputs
Outputs of similar age from Drug Design, Development and Therapy
#4
of 39 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 206,704 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.