https://t.co/ObCYjtA04A "In addition, combination therapy with clofoctol and sorafenib markedly inhibited the growth of prostate cancer xenograft tumors, compared with clofoctol or sorafenib alone."
https://t.co/ObCYjtA04A "Combination therapy with clofoctol and sorafenib induced an upregulation of markers of all three ER stress pathways: PERK, IRE1 and ATF6."
Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways https://t.co/ObCYjtA04A
https://t.co/zjR9c8L8JK "Sorafenib alone does not cause accumulation of ubiquitinated modified proteins, but sorafenib enhances clofoctol’s action when used in combination."
https://t.co/zjR9c8L8JK "In addition, we found that clofoctol induces the accumulation of ubiquitinated modified proteins, which is a general indicator of the inhibition of ubiquitin proteasome system (UPS) function."
https://t.co/zjR9c8L8JK "Sorafenib is a multi-kinase inhibitor and tyrosine kinase receptor of the Raf/MEK/ERK pathway and has been shown to induce apoptosis and inhibit proliferation and angiogenesis in a variety of tumor cells."
https://t.co/zjR9c8L8JK "The study also showed that clofoctol exerts its anticancer effect through activation of endoplasmic reticulum (ER) stress and all three unfolded protein response (UPR) pathways."
https://t.co/zjR9c8L8JK "In addition, combination therapy with clofoctol and sorafenib markedly inhibited the growth of prostate cancer xenograft tumors, compared with clofoctol or sorafenib alone."
https://t.co/zjR9c8L8JK "Combination therapy with clofoctol and sorafenib induced an upregulation of markers of all three ER stress pathways: PERK, IRE1 and ATF6."
https://t.co/zjR9c8L8JK "Our data indicate that clofototol and sorafenib induce cell death through synergistic induction of endoplasmic reticulum (ER) stress, resulting in activation of the unfolded protein response (UPR)."
Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways #MECFS #LongCovid https://t.co/zjR9c8L8JK