| Title |
Influence of rs1080985 single nucleotide polymorphism of the CYP2D6 gene on response to treatment with donepezil in patients with Alzheimer’s disease
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, July 2013
|
| DOI | 10.2147/ndt.s46689 |
| Pubmed ID | |
| Authors |
Aleksandra Klimkowicz-Mrowiec, Pawel Wolkow, Malgorzata Sado, ANNA Dziubek, Joanna Pera, Tomasz Dziedzic, Andrzej Szczudlik, Agnieszka Slowik |
| Abstract |
Recent data indicate that the rs1080985 single nucleotide polymorphism of the cytochrome P450 (CYP) 2D6 gene may affect the response to treatment with donepezil in patients with Alzheimer's disease. There is also evidence that the common apolipoprotein E (APOE) polymorphism may affect the response to treatment with donepezil in Alzheimer's disease. We investigated the association between response to donepezil and the rs1080985 single nucleotide polymorphism, the minor allele (G) of which was previously reported to be associated with a poor response to this drug in patients with Alzheimer's disease. The common APOE polymorphism was also assessed for its relevance to the outcome of this treatment. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 29% |
| Researcher | 4 | 14% |
| Student > Master | 2 | 7% |
| Student > Ph. D. Student | 2 | 7% |
| Student > Doctoral Student | 1 | 4% |
| Other | 4 | 14% |
| Unknown | 7 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 21% |
| Medicine and Dentistry | 4 | 14% |
| Agricultural and Biological Sciences | 3 | 11% |
| Neuroscience | 3 | 11% |
| Computer Science | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 8 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2013.
All research outputs
#16,722,190
of 25,374,917 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,718
of 3,132 outputs
Outputs of similar age
#126,356
of 206,711 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#40
of 63 outputs
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We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.