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Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
1 news outlet
twitter
5 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
83 Dimensions

Readers on

mendeley
74 Mendeley
Title
Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update
Published in
International Journal of Chronic Obstructive Pulmonary Disease, February 2017
DOI 10.2147/copd.s125389
Pubmed ID
Authors

Ignacio Blanco, Patricia Bueno, Isidro Diego, Sergio Pérez-Holanda, Francisco Casas-Maldonado, Cristina Esquinas, Marc Miravitlles

Abstract

In alpha-1 antitrypsin deficiency (AATD), the Z allele is present in 98% of cases with severe disease, and knowledge of the frequency of this allele is essential from a public health perspective. However, there is a remarkable lack of epidemiological data on AATD worldwide, and many of the data currently used are outdated. Therefore, the objective of this study was to update the knowledge of the frequency of the Z allele to achieve accurate estimates of the prevalence and number of Pi*ZZ genotypes worldwide based on studies performed according to the following criteria: 1) samples representative of the general population, 2) AAT phenotyping characterized by adequate methods, and 3) measurements performed using a coefficient of variation calculated from the sample size and 95% confidence intervals. Studies fulfilling these criteria were used to develop maps with an inverse distance weighted (IDW)-interpolation method, providing numerical and graphical information of Pi*Z distribution worldwide. A total of 224 cohorts from 65 countries were included in the study. With the data provided by these cohorts, a total of 253,404 Pi*ZZ were estimated worldwide: 119,594 in Europe, 91,490 in America and Caribbean, 3,824 in Africa, 32,154 in Asia, 4,126 in Australia, and 2,216 in New Zealand. In addition, the IDW-interpolation maps predicted Pi*Z frequencies throughout the world even in some areas that lack real data. In conclusion, the inclusion of new well-designed studies and the exclusion of the low-quality ones have significantly improved the reliability of results, which may be useful to plan strategies for future research and diagnosis and to rationalize the therapeutic resources available.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 23%
Other 11 15%
Student > Bachelor 8 11%
Student > Master 6 8%
Student > Ph. D. Student 5 7%
Other 7 9%
Unknown 20 27%
Readers by discipline Count As %
Medicine and Dentistry 22 30%
Biochemistry, Genetics and Molecular Biology 9 12%
Agricultural and Biological Sciences 6 8%
Nursing and Health Professions 3 4%
Immunology and Microbiology 3 4%
Other 8 11%
Unknown 23 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2020.
All research outputs
#2,124,302
of 19,311,167 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#238
of 2,105 outputs
Outputs of similar age
#44,213
of 272,455 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#12
of 65 outputs
Altmetric has tracked 19,311,167 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.