| Title |
S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis
|
|---|---|
| Published in |
Drug Design, Development and Therapy, June 2013
|
| DOI | 10.2147/dddt.s43930 |
| Pubmed ID | |
| Authors |
Daniel FC Mazo, Marcelo G de Oliveira, Isabel VA Pereira, Bruno Cogliati, José T Stefano, Gabriela FP de Souza, Fabíola Rabelo, Fabiana R Lima, Venâncio A Ferreira Alves, Flair J Carrilho, Claudia PMS de Oliveira |
| Abstract |
S-Nitroso-N-acetylcysteine (SNAC) is a water soluble primary S-nitrosothiol capable of transferring and releasing nitric oxide and inducing several biochemical activities, including modulation of hepatic stellate cell activation. In this study, we evaluated the antifibrotic activity of SNAC in an animal model of nonalcoholic steatohepatitis (NASH) induced in Sprague-Dawley rats fed with a choline-deficient, high trans fat diet and exposed to diethylnitrosamine for 8 weeks. The rats were divided into three groups: SNAC, which received oral SNAC solution daily; NASH, which received the vehicle; and control, which received standard diet and vehicle. Genes related to fibrosis (matrix metalloproteinases [MMP]-13, -9, and -2), transforming growth factor β-1 [TGFβ-1], collagen-1α, and tissue inhibitors of metalloproteinase [TIMP-1 and -2] and oxidative stress (heat-shock proteins [HSP]-60 and -90) were evaluated. SNAC led to a 34.4% reduction in the collagen occupied area associated with upregulation of MMP-13 and -9 and downregulation of HSP-60, TIMP-2, TGFβ-1, and collagen-1α. These results indicate that oral SNAC administration may represent a potential antifibrotic treatment for NASH. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 26% |
| Student > Bachelor | 7 | 15% |
| Student > Ph. D. Student | 7 | 15% |
| Student > Master | 5 | 11% |
| Student > Doctoral Student | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 10 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Chemistry | 5 | 11% |
| Medicine and Dentistry | 5 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
| Other | 6 | 13% |
| Unknown | 14 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2013.
All research outputs
#20,110,957
of 25,584,565 outputs
Outputs from Drug Design, Development and Therapy
#1,299
of 2,254 outputs
Outputs of similar age
#150,411
of 206,928 outputs
Outputs of similar age from Drug Design, Development and Therapy
#15
of 20 outputs
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