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Update on oncolytic viral therapy – targeting angiogenesis

Overview of attention for article published in OncoTargets and therapy, July 2013
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About this Attention Score

  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter

Citations

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10 Dimensions

Readers on

mendeley
35 Mendeley
Title
Update on oncolytic viral therapy – targeting angiogenesis
Published in
OncoTargets and therapy, July 2013
DOI 10.2147/ott.s46974
Pubmed ID
Authors

James Tysome, Nick Lemoine, Yaohe Wang

Abstract

Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic therapy with OVs. Angiogenesis can be targeted either directly by OV infection of vascular endothelial cells, or by arming OVs with antiangiogenic transgenes, which are subsequently expressed locally in the tumor microenvironment. In this review, we describe the development and targeting of OVs, the role of angiogenesis in cancer, and the progress made in arming viruses with antiangiogenic transgenes. Future developments required to optimize this approach are addressed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Bachelor 9 26%
Student > Ph. D. Student 7 20%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Other 3 9%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 43%
Biochemistry, Genetics and Molecular Biology 5 14%
Immunology and Microbiology 4 11%
Medicine and Dentistry 3 9%
Chemistry 2 6%
Other 1 3%
Unknown 5 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2013.
All research outputs
#9,985,581
of 12,475,053 outputs
Outputs from OncoTargets and therapy
#802
of 1,548 outputs
Outputs of similar age
#105,246
of 154,028 outputs
Outputs of similar age from OncoTargets and therapy
#17
of 35 outputs
Altmetric has tracked 12,475,053 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,548 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,028 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.