Title |
Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment
|
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Published in |
International Journal of Nanomedicine, February 2017
|
DOI | 10.2147/ijn.s127256 |
Pubmed ID | |
Authors |
Zhen Zhang, Hanqing Qian, Mi Yang, Rutian Li, Jing Hu, Li Li, Lixia Yu, Baorui Liu, Xiaoping Qian |
Abstract |
Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic-co-glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 13 | 22% |
Student > Ph. D. Student | 10 | 17% |
Student > Bachelor | 4 | 7% |
Researcher | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 10% |
Unknown | 19 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 31% |
Materials Science | 5 | 8% |
Agricultural and Biological Sciences | 4 | 7% |
Medicine and Dentistry | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 5 | 8% |
Unknown | 22 | 37% |