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Article Metrics

Engineered nanomaterial uptake and tissue distribution: from cell to organism

Overview of attention for article published in International Journal of Nanomedicine, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

policy
1 policy source
twitter
4 tweeters
googleplus
1 Google+ user

Citations

dimensions_citation
172 Dimensions

Readers on

mendeley
204 Mendeley
Title
Engineered nanomaterial uptake and tissue distribution: from cell to organism
Published in
International Journal of Nanomedicine, August 2013
DOI 10.2147/ijn.s49770
Pubmed ID
Authors

Joerg Huwyler, Helene Kettiger, Angela Schipanski, Peter Wick

Abstract

Improved understanding of interactions between nanoparticles and biological systems is needed to develop safety standards and to design new generations of nanomaterials. This article reviews the molecular mechanisms of cellular uptake of engineered nanoparticles, their intracellular fate, and their distribution within an organism. We have reviewed the available literature on the uptake and disposition of engineered nanoparticles. Special emphasis was placed on the analysis of experimental systems and their limitations with respect to their usefulness to predict the in vivo situation. The available literature confirms the need to study particle characteristics in an environment that simulates the situation encountered in biological systems. Phenomena such as protein binding and opsonization are of prime importance since they may have a strong impact on cellular internalization, biodistribution, and immunogenicity of nanoparticles in vitro and in vivo. Extrapolation from in vitro results to the in vivo situation in the whole organism remains a challenge. However, improved understanding of physicochemical properties of engineered nanoparticles and their influence on biological systems facilitates the design of nanomaterials that are safe, well tolerated, and suitable for diagnostic or therapeutic use in humans.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 204 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 <1%
Colombia 1 <1%
Germany 1 <1%
Bulgaria 1 <1%
Korea, Republic of 1 <1%
Italy 1 <1%
Brazil 1 <1%
Saudi Arabia 1 <1%
Mexico 1 <1%
Other 2 <1%
Unknown 192 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 24%
Researcher 37 18%
Student > Master 37 18%
Student > Doctoral Student 13 6%
Student > Bachelor 13 6%
Other 33 16%
Unknown 23 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 46 23%
Chemistry 21 10%
Pharmacology, Toxicology and Pharmaceutical Science 20 10%
Medicine and Dentistry 18 9%
Biochemistry, Genetics and Molecular Biology 16 8%
Other 47 23%
Unknown 36 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2017.
All research outputs
#4,583,188
of 22,719,618 outputs
Outputs from International Journal of Nanomedicine
#390
of 3,796 outputs
Outputs of similar age
#40,118
of 198,395 outputs
Outputs of similar age from International Journal of Nanomedicine
#15
of 104 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,796 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 104 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.