Title |
Identification of PPARγ ligands with One-dimensional Drug Profile Matching
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Published in |
Drug Design, Development and Therapy, September 2013
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DOI | 10.2147/dddt.s47173 |
Pubmed ID | |
Authors |
Diána Kovács, Zoltán Simon, Péter Hári, András Málnási-Csizmadia, Csaba Hegedűs, László Drimba, József Németh, Réka Sári, Zoltán Szilvássy, Barna Peitl |
Abstract |
Computational molecular database screening helps to decrease the time and resources needed for drug development. Reintroduction of generic drugs by second medical use patents also contributes to cheaper and faster drug development processes. We screened, in silico, the Food and Drug Administration-approved generic drug database by means of the One-dimensional Drug Profile Matching (oDPM) method in order to find potential peroxisome proliferator-activated receptor gamma (PPARγ) agonists. The PPARγ action of the selected generics was also investigated by in vitro and in vivo experiments. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 22% |
Researcher | 5 | 19% |
Student > Doctoral Student | 2 | 7% |
Student > Bachelor | 2 | 7% |
Lecturer > Senior Lecturer | 2 | 7% |
Other | 5 | 19% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 30% |
Computer Science | 3 | 11% |
Agricultural and Biological Sciences | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Chemistry | 2 | 7% |
Other | 6 | 22% |
Unknown | 3 | 11% |