Title |
Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
|
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Published in |
International Journal of Nanomedicine, September 2013
|
DOI | 10.2147/ijn.s51203 |
Pubmed ID | |
Authors |
Jianhua Li, Na Ren, Jichuan Qiu, Xiaoning Mou, Hong Liu |
Abstract |
A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 2% |
Unknown | 55 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 27% |
Student > Master | 8 | 14% |
Student > Bachelor | 4 | 7% |
Professor > Associate Professor | 4 | 7% |
Researcher | 3 | 5% |
Other | 8 | 14% |
Unknown | 14 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 10 | 18% |
Engineering | 8 | 14% |
Materials Science | 5 | 9% |
Agricultural and Biological Sciences | 4 | 7% |
Environmental Science | 3 | 5% |
Other | 8 | 14% |
Unknown | 18 | 32% |