| Title |
Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
|
|---|---|
| Published in |
The Application of Clinical Genetics, July 2013
|
| DOI | 10.2147/tacg.s35605 |
| Pubmed ID | |
| Authors |
D Gareth R Evans, Sarah Louise Ingham |
| Abstract |
There are several hereditary diseases that are a predisposition to early-onset tumors. These include syndromic conditions like neurofibromatosis 1 and 2, von Hippel-Lindau syndrome, Gorlin syndrome, multiple endocrine neoplasia, and familial adenomatous polyposis; and conditions which are usually not possible to diagnose clinically in a single individual, such as Lynch syndrome and BRCA1/2. Understanding of the mortality in hereditary cancer predisposing diseases is important for developing effective disease treatment programs. A number of studies have been undertaken to investigate the genetic predictors, prevalence and incidence, and treatment outcomes of these diseases; however, the majority examine only the most common of these diseases (eg, neurofibromatosis or BRCA), or look into postoperative survival. The mortality of individuals who are diagnosed with one of these hereditary diseases remains an area for investigation. This review is the first to attempt identification of studies investigating life expectancy in hereditary diseases which predispose to early-onset tumors. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 53 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 15% |
| Student > Bachelor | 6 | 11% |
| Student > Ph. D. Student | 6 | 11% |
| Other | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Other | 8 | 15% |
| Unknown | 17 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 34% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Agricultural and Biological Sciences | 6 | 11% |
| Nursing and Health Professions | 2 | 4% |
| Social Sciences | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 16 | 30% |
Attention Score in Context
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