| Title |
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
|
|---|---|
| Published in |
OncoTargets and therapy, September 2013
|
| DOI | 10.2147/ott.s36162 |
| Pubmed ID | |
| Authors |
Ingrid Espinoza, Radhika Pochampally, Fei Xing, Kounosuke Watabe, Lucio Miele |
| Abstract |
Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the "stemness" program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 146 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 30% |
| Student > Master | 25 | 17% |
| Student > Bachelor | 22 | 15% |
| Researcher | 15 | 10% |
| Student > Postgraduate | 8 | 5% |
| Other | 14 | 9% |
| Unknown | 19 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 32% |
| Medicine and Dentistry | 31 | 21% |
| Biochemistry, Genetics and Molecular Biology | 23 | 16% |
| Immunology and Microbiology | 5 | 3% |
| Chemistry | 4 | 3% |
| Other | 14 | 9% |
| Unknown | 23 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2019.
All research outputs
#7,206,202
of 25,540,105 outputs
Outputs from OncoTargets and therapy
#369
of 3,021 outputs
Outputs of similar age
#58,631
of 212,816 outputs
Outputs of similar age from OncoTargets and therapy
#6
of 35 outputs
Altmetric has tracked 25,540,105 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,021 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.