| Title |
Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis
|
|---|---|
| Published in |
Drug Design, Development and Therapy, July 2013
|
| DOI | 10.2147/dddt.s49197 |
| Pubmed ID | |
| Authors |
Qingli Li, Mark J Lambrechts, Qiuyang Zhang, Sen Liu, Dongxia Ge, Rutie Yin, Mingrong Xi, Zongbing You |
| Abstract |
Glycine is a nonessential amino acid that is reversibly converted from serine intracellularly by serine hydroxymethyltransferase. Glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), are analogs to glycine, thus they may inhibit serine hydroxymethyltransferase to decrease intracellular glycine synthesis. In this study, we found that glyphosate and AMPA inhibited cell growth in eight human cancer cell lines but not in two immortalized human normal prostatic epithelial cell lines. AMPA arrested C4-2B and PC-3 cancer cells in the G1/G0 phase and inhibited entry into the S phase of the cell cycle. AMPA also promoted apoptosis in C4-2B and PC-3 cancer cell lines. AMPA upregulated p53 and p21 protein levels as well as procaspase 9 protein levels in C4-2B cells, whereas it downregulated cyclin D3 protein levels. AMPA also activated caspase 3 and induced cleavage of poly (adenosine diphosphate [ADP]-ribose) polymerase. This study provides the first evidence that glyphosate and AMPA can inhibit proliferation and promote apoptosis of cancer cells but not normal cells, suggesting that they have potentials to be developed into a new anticancer therapy. |
X Demographics
The data shown below were collected from the profiles of 619 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 195 | 32% |
| United States | 43 | 7% |
| Canada | 21 | 3% |
| France | 19 | 3% |
| United Kingdom | 15 | 2% |
| Australia | 7 | 1% |
| Chile | 6 | <1% |
| Peru | 4 | <1% |
| Philippines | 4 | <1% |
| Other | 27 | 4% |
| Unknown | 278 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 576 | 93% |
| Scientists | 36 | 6% |
| Practitioners (doctors, other healthcare professionals) | 6 | <1% |
| Science communicators (journalists, bloggers, editors) | 2 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Unknown | 100 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 18% |
| Student > Bachelor | 16 | 16% |
| Researcher | 14 | 14% |
| Student > Ph. D. Student | 10 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 11 | 11% |
| Unknown | 27 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 26% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Chemistry | 8 | 8% |
| Medicine and Dentistry | 8 | 8% |
| Environmental Science | 6 | 6% |
| Other | 11 | 11% |
| Unknown | 29 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 459. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2023.
All research outputs
#61,140
of 25,847,449 outputs
Outputs from Drug Design, Development and Therapy
#8
of 2,284 outputs
Outputs of similar age
#319
of 207,689 outputs
Outputs of similar age from Drug Design, Development and Therapy
#1
of 39 outputs
Altmetric has tracked 25,847,449 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,284 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.