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Dove Medical Press

Gamma secretase inhibitors of Notch signaling

Overview of attention for article published in OncoTargets and therapy, July 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
1 X user
patent
13 patents

Citations

dimensions_citation
152 Dimensions

Readers on

mendeley
232 Mendeley
Title
Gamma secretase inhibitors of Notch signaling
Published in
OncoTargets and therapy, July 2013
DOI 10.2147/ott.s33766
Pubmed ID
Authors

Roma Olsauskas-Kuprys, Andrei Zlobin, Clodia Osipo

Abstract

The numerous processes involved in the etiology of breast cancer such as cell survival, metabolism, proliferation, differentiation, and angiogenesis are currently being elucidated. However, underlying mechanisms that drive breast cancer progression and drug resistance are still poorly understood. As we discuss here in detail, the Notch signaling pathway is an important regulatory component of normal breast development, cell fate of normal breast stem cells, and proliferation and survival of breast cancer initiating cells. Notch exerts a wide range of critical effects through a canonical pathway where it is expressed as a type I membrane precursor heterodimer followed by at least two subsequent cleavages induced by ligand engagement to ultimately release an intracellular form to function as a transcriptional activator. Notch and its ligands are overexpressed in breast cancer, and one method of effectively blocking Notch activity is preventing its cleavage at the cell surface with γ-secretase inhibitors. In the context of Notch signaling, the application of clinically relevant anti-Notch drugs in treatment regimens may contribute to novel therapeutic interventions and promote more effective clinical response in women with breast cancer.

Timeline
X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 232 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
France 2 <1%
India 1 <1%
Germany 1 <1%
Unknown 224 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 25%
Researcher 37 16%
Student > Master 33 14%
Student > Bachelor 33 14%
Student > Doctoral Student 9 4%
Other 23 10%
Unknown 38 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 68 29%
Biochemistry, Genetics and Molecular Biology 61 26%
Medicine and Dentistry 24 10%
Chemistry 9 4%
Immunology and Microbiology 8 3%
Other 22 9%
Unknown 40 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2023.
All research outputs
#3,811,353
of 26,106,397 outputs
Outputs from OncoTargets and therapy
#136
of 3,020 outputs
Outputs of similar age
#30,527
of 208,097 outputs
Outputs of similar age from OncoTargets and therapy
#5
of 42 outputs
Altmetric has tracked 26,106,397 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,020 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 208,097 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.