| Title |
Enzyme replacement therapy for pancreatic insufficiency: present and future
|
|---|---|
| Published in |
Clinical and Experimental Gastroenterology, May 2011
|
| DOI | 10.2147/ceg.s17634 |
| Pubmed ID | |
| Authors |
Aaron Fieker, Jessica Philpott, Martine Armand |
| Abstract |
Pancreatic enzyme replacement therapy is currently the mainstay of treatment for nutrient malabsorption secondary to pancreatic insufficiency. This treatment is safe and has few side effects. Data demonstrate efficacy in reducing steatorrhea and fat malabsorption. Effective therapy has been limited by the ability to replicate the physiologic process of enzyme delivery to the appropriate site, in general the duodenum, at the appropriate time. The challenges include enzyme destruction in the stomach, lack of adequate mixing with the chyme in the duodenum, and failing to deliver and activate at the appropriate time. Treatment is begun when clinically significant malabsorption occurs resulting in steatorrhea and weight loss. Treatment failure is addressed in a sequential fashion. Current research is aimed at studying new enzymes and delivery systems to improve the efficiency of action in the duodenum along with developing better means to monitor therapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| United States | 2 | <1% |
| Australia | 2 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 272 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 57 | 20% |
| Student > Master | 35 | 12% |
| Researcher | 32 | 11% |
| Student > Ph. D. Student | 31 | 11% |
| Other | 26 | 9% |
| Other | 39 | 14% |
| Unknown | 61 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 81 | 29% |
| Agricultural and Biological Sciences | 43 | 15% |
| Biochemistry, Genetics and Molecular Biology | 25 | 9% |
| Nursing and Health Professions | 22 | 8% |
| Engineering | 9 | 3% |
| Other | 29 | 10% |
| Unknown | 72 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2024.
All research outputs
#998,598
of 23,394,907 outputs
Outputs from Clinical and Experimental Gastroenterology
#11
of 312 outputs
Outputs of similar age
#3,846
of 111,511 outputs
Outputs of similar age from Clinical and Experimental Gastroenterology
#1
of 2 outputs
Altmetric has tracked 23,394,907 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 312 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,511 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them