Title |
Axitinib versus sorafenib as a second-line therapy in Asian patients with metastatic renal cell carcinoma: results from a randomized registrational study
|
---|---|
Published in |
OncoTargets and therapy, June 2015
|
DOI | 10.2147/ott.s83302 |
Pubmed ID | |
Authors |
Vardit Dror, Shukui Qin, Connie Chen, Sinil Kim, Dingwei Ye, Feng Bi, Jie Jin, Ying Cheng, Jun Guo, Xiubao Ren, Yiran Huang, Jamal Tarazi, Jie Tang |
Abstract |
This registrational trial evaluated the efficacy, safety, and patient-reported outcomes of axitinib versus sorafenib as a second-line treatment in Asian patients with clear-cell metastatic renal cell carcinoma (mRCC). In this open-label, multicenter study, previously treated Asian patients with clear-cell mRCC were stratified by Eastern Cooperative Oncology Group performance status and prior therapy and randomized in a 2:1 ratio to receive axitinib (5 mg twice daily) or sorafenib (400 mg twice daily). The primary end point was progression-free survival (PFS) assessed by a masked independent review committee. A total of 204 Asian patients received axitinib (n=135) or sorafenib (n=69). Median PFS (95% confidence interval [CI]) was 6.5 (4.7-9.1) months with axitinib versus 4.8 (3.0-6.5) months with sorafenib (hazard ratio, 0.731; 95% CI, 0.506-1.058; one-sided P=0.0531). The objective response rate (95% CI) was 23.7% (16.8%-31.8%) with axitinib versus 10.1% (4.2%-19.8%) with sorafenib. Common, grade ≥3, all-causality adverse events were hypertension (19.3%), weight decrease (5.2%), and proteinuria (5.2%) with axitinib and hypertension (8.7%) and palmar-plantar erythrodysesthesia (7.2%) with sorafenib. In a time-to-deterioration composite end point of death, progression, and worsening of Functional Assessment of Cancer Therapy Kidney Symptom Index score, patients treated with axitinib demonstrated a 17%-24% risk reduction compared with sorafenib-treated patients. Axitinib is clinically active and well tolerated in previously treated Asian patients with mRCC, consistent with the results from the global Phase III trial. These results establish axitinib as a second-line treatment option for Asian patients with mRCC. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 14% |
Student > Master | 4 | 14% |
Other | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Other | 2 | 7% |
Unknown | 12 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 32% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Business, Management and Accounting | 1 | 4% |
Other | 2 | 7% |
Unknown | 13 | 46% |