Title |
Mechanism of enhanced oral absorption of hydrophilic drug incorporated in hydrophobic nanoparticles
|
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Published in |
International Journal of Nanomedicine, July 2013
|
DOI | 10.2147/ijn.s47400 |
Pubmed ID | |
Authors |
Liang-Zhong Lv, Chen-Qi Tong, Jia Yu, Min Han, Jian-Qing Gao |
Abstract |
Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L, which has high water solubility and low oral bioavailability. This research aims to develop a hydrophobic nanoparticle that can enhance the oral absorption of HSYA. Transmission electron microscopy and freeze-fracture replication transmission election microscopy showed that the HSYA nanoparticles have an irregular shape and a narrow size distribution. Zonula occludens 1 protein (ZO-1) labeling showed that the nanoparticles with different dilutions produced an opening in the tight junctions of Caco-2 cells without inducing cytotoxicity to the cells. Both enhanced uptake in Caco-2 cells monolayer and increased bioavailability in rats for HSYA nanoparticles indicated that the formulation could improve bioavailability of HSYA significantly after oral administration both in vitro and in vivo. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 33% |
Researcher | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Lecturer > Senior Lecturer | 1 | 6% |
Student > Master | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 28% |
Chemistry | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Chemical Engineering | 1 | 6% |
Other | 1 | 6% |
Unknown | 6 | 33% |