| Title |
A train of blue light pulses delivered through closed eyelids suppresses melatonin and phase shifts the human circadian system
|
|---|---|
| Published in |
Nature and science of sleep, October 2013
|
| DOI | 10.2147/nss.s52203 |
| Pubmed ID | |
| Authors |
Mariana G Figueiro, Andrew Bierman, Mark S Rea |
| Abstract |
A model of circadian phototransduction was published in 2005 to predict the spectral sensitivity of the human circadian system to narrow-band and polychromatic light sources by combining responses to light from the spectral-opponent "blue" versus "yellow" cone bipolar pathway with direct responses to light by the intrinsically photosensitive retinal ganglion cells. In the model, depolarizing "blue" responses, but not hyperpolarizing "yellow" responses, from the "blue" versus "yellow" pathway are combined with the intrinsically photosensitive retinal ganglion cell responses. Intrinsically photosensitive retinal ganglion cell neurons are known to be much slower to respond to light than the cone pathway, so an implication of the model is that periodic flashes of "blue" light, but not "yellow" light, would be effective for stimulating the circadian system. A within-subjects study was designed to test the implications of the model regarding retinal exposures to brief flashes of light. The study was also aimed at broadening the foundation for clinical treatment of circadian sleep disorders by delivering flashing light through closed eyelids while people were asleep. In addition to a dark control night, the eyelids of 16 subjects were exposed to three light-stimulus conditions in the phase delay portion of the phase response curve while they were asleep: (1) 2-second flashes of 111 W/m(2) of blue (λmax ≈ 480 nm) light once every minute for 1 hour, (2) 131 W/m(2) of green (λmax ≈ 527 nm) light, continuously on for 1 hour, and (3) 2-second flashes of the same green light once every minute for 1 hour. Inferential statistics showed that the blue flash light-stimulus condition significantly delayed circadian phase and significantly suppressed nocturnal melatonin. The results of this study further our basic understanding of circadian phototransduction and broaden the technical foundations for delivering light through closed eyelids during sleep for treating circadian sleep disorders. |
X Demographics
The data shown below were collected from the profiles of 54 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 8 | 15% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Argentina | 2 | 4% |
| Peru | 1 | 2% |
| Canada | 1 | 2% |
| United States | 1 | 2% |
| Finland | 1 | 2% |
| Egypt | 1 | 2% |
| Unknown | 37 | 69% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 50 | 93% |
| Practitioners (doctors, other healthcare professionals) | 3 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Spain | 2 | 2% |
| France | 1 | 1% |
| Russia | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 84 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Other | 7 | 8% |
| Other | 16 | 18% |
| Unknown | 16 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 14% |
| Medicine and Dentistry | 10 | 11% |
| Psychology | 9 | 10% |
| Engineering | 8 | 9% |
| Neuroscience | 7 | 8% |
| Other | 25 | 27% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2022.
All research outputs
#890,607
of 25,371,288 outputs
Outputs from Nature and science of sleep
#71
of 629 outputs
Outputs of similar age
#7,824
of 219,840 outputs
Outputs of similar age from Nature and science of sleep
#1
of 3 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 629 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.5. This one has done well, scoring higher than 88% of its peers.
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