| Title |
8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
|
|---|---|
| Published in |
Drug Design, Development and Therapy, October 2013
|
| DOI | 10.2147/dddt.s49763 |
| Pubmed ID | |
| Authors |
Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul |
| Abstract |
Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure-activity relationships. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 352 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Germany | 1 | <1% |
| Bulgaria | 1 | <1% |
| Australia | 1 | <1% |
| Sweden | 1 | <1% |
| United States | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 344 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 68 | 19% |
| Researcher | 43 | 12% |
| Student > Master | 40 | 11% |
| Student > Bachelor | 34 | 10% |
| Other | 15 | 4% |
| Other | 55 | 16% |
| Unknown | 97 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 104 | 30% |
| Biochemistry, Genetics and Molecular Biology | 35 | 10% |
| Agricultural and Biological Sciences | 28 | 8% |
| Medicine and Dentistry | 16 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 5% |
| Other | 47 | 13% |
| Unknown | 106 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2021.
All research outputs
#7,968,340
of 25,394,764 outputs
Outputs from Drug Design, Development and Therapy
#543
of 2,270 outputs
Outputs of similar age
#67,976
of 219,927 outputs
Outputs of similar age from Drug Design, Development and Therapy
#11
of 39 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,270 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,927 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.