Title |
Potential use of mesenchymal stem cells in human meniscal repair: current insights
|
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Published in |
Open Access Journal of Sports Medicine, March 2017
|
DOI | 10.2147/oajsm.s113018 |
Pubmed ID | |
Authors |
Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Jeong Ho Jeon, Sang Hee Lee |
Abstract |
The menisci of the human knee play an important role in maintaining normal functions to provide stability and nutrition to the articular cartilage, and to absorb shock. Once injured, these important structures have very limited natural healing potential. Unfortunately, the traditional arthroscopic meniscectomy performed on these damaged menisci may predispose the joint toward early development of osteoarthritis. Although a very limited number of studies are available, mesenchymal stem cells (MSCs) have been investigated as an alternative therapeutic modality to repair human knee meniscal tears. This review summarizes the results of published applications of MSCs in human patients, which showed that the patients who received MSCs (autologous adipose tissue-derived stem cells or culture-expanded bone marrow-derived stem cells) presented symptomatic improvements, along with magnetic resonance imaging evidences of the meniscal repair. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 11% |
Italy | 1 | 11% |
Unknown | 7 | 78% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 10 | 17% |
Researcher | 9 | 15% |
Student > Ph. D. Student | 7 | 12% |
Other | 5 | 8% |
Student > Bachelor | 4 | 7% |
Other | 5 | 8% |
Unknown | 19 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 39% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Agricultural and Biological Sciences | 4 | 7% |
Engineering | 4 | 7% |
Immunology and Microbiology | 1 | 2% |
Other | 2 | 3% |
Unknown | 21 | 36% |