Title |
Salvage treatment with apatinib for advanced non-small-cell lung cancer
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Published in |
OncoTargets and therapy, March 2017
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DOI | 10.2147/ott.s113435 |
Pubmed ID | |
Authors |
Zhengbo Song, Xinmin Yu, Guangyuan Lou, Xun Shi, Yiping Zhang |
Abstract |
No definitive chemotherapeutic regimen has been established in patients with non-small-cell lung cancer (NSCLC) who failed second- or third-line treatment. The aim of this study was to evaluate apatinib, a VEGFR-2 inhibitor, in advanced NSCLC as salvage treatment. We evaluated the efficacy and toxicity of apatinib in patients with previously treated advanced NSCLC from 2014 to 2015 in Zhejiang Cancer Hospital. Survival analysis was performed by the Kaplan-Meier method. Forty-two patients were included in the present study. Four patients achieved partial response, and 22 achieved stable disease, representing a response rate of 9.5% and a disease control rate of 61.9%. Median progression-free survival and overall survival were 4.2 and 6.0 months, respectively. The toxicities associated with apatinib were generally acceptable with a total grade 3/4 toxicity of 50%. Apatinib appears to have some activity against advanced NSCLC when utilized as salvage treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 2 | 17% |
Other | 1 | 8% |
Student > Bachelor | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Other | 1 | 8% |
Unknown | 5 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 25% |
Agricultural and Biological Sciences | 2 | 17% |
Physics and Astronomy | 1 | 8% |
Earth and Planetary Sciences | 1 | 8% |
Materials Science | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |