Title |
Selegiline remarkably improved stage 5 treatment-resistant major depressive disorder: a case report
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Published in |
Neuropsychiatric Disease and Treatment, October 2013
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DOI | 10.2147/ndt.s49261 |
Pubmed ID | |
Authors |
Yuji Kitaichi, Takeshi Inoue, Nobuyuki Mitsui, Shin Nakagawa, Rie Kameyama, Yoshiyuki Hayashishita, Tohru Shiga, Ichiro Kusumi, Tsukasa Koyama |
Abstract |
We report a case in which selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, greatly improved depressive symptoms in an adult with stage 5 treatment-resistant major depressive disorder. Four antidepressants and four augmentation therapies had previously been ineffective or intolerable, and electroconvulsive therapy had only a temporary effect. After 20 weeks of treatment with selegiline (10 mg/day), the patient's score on the 17-item Hamilton Depression Rating Scale (HDRS) had decreased from 19 to 4 points. [(18)F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased glucose metabolism in the bilateral basal ganglia after initiating selegiline treatment; blood dopamine levels were also increased after selegiline treatment. These results raise the possibility that selegiline enhances dopamin-ergic neural transmission in treatment-resistant depression, thus leading to an improvement in depressive symptoms. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 23% |
Student > Bachelor | 4 | 13% |
Other | 2 | 6% |
Professor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 6 | 19% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 39% |
Neuroscience | 5 | 16% |
Psychology | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 26% |