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Role of leptin resistance in the development of obesity in older patients

Overview of attention for article published in Clinical Interventions in Aging, July 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
71 Dimensions

Readers on

mendeley
97 Mendeley
Title
Role of leptin resistance in the development of obesity in older patients
Published in
Clinical Interventions in Aging, July 2013
DOI 10.2147/cia.s36367
Pubmed ID
Authors

Frédéric Picard, Sophie Carter, Alexandre Caron, Denis Richard

Abstract

Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally, leptin controls food intake, energy expenditure, and fat distribution, whereas it controls (among several others) insulin sensitivity, free fatty acids (FFAs) oxidation, and lipolysis in the periphery. Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are also associated with leptin resistance. This resistance blunts normal central and peripheral functions of leptin, which leads to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Here, we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients. Furthermore, we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 97 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 5%
Student > Master 5 5%
Researcher 4 4%
Student > Bachelor 4 4%
Lecturer > Senior Lecturer 1 1%
Other 4 4%
Unknown 74 76%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 8%
Agricultural and Biological Sciences 5 5%
Medicine and Dentistry 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Nursing and Health Professions 1 1%
Other 3 3%
Unknown 74 76%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2013.
All research outputs
#2,071,033
of 5,028,713 outputs
Outputs from Clinical Interventions in Aging
#268
of 721 outputs
Outputs of similar age
#38,423
of 106,869 outputs
Outputs of similar age from Clinical Interventions in Aging
#14
of 46 outputs
Altmetric has tracked 5,028,713 research outputs across all sources so far. This one has received more attention than most of these and is in the 57th percentile.
So far Altmetric has tracked 721 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,869 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.