Title |
Reduced dorsolateral prefrontal cortical hemodynamic response in adult obsessive-compulsive disorder as measured by near-infrared spectroscopy during the verbal fluency task
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Published in |
Neuropsychiatric Disease and Treatment, July 2013
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DOI | 10.2147/ndt.s45402 |
Pubmed ID | |
Authors |
Rikuei Hirosawa, Jin Narumoto, Yuki Sakai, Seiji Nishida, Takuya Ishida, Takashi Nakamae, Yuichi Takei, Kenji Fukui |
Abstract |
Near-infrared spectroscopy has helped our understanding of the neurobiological mechanisms of psychiatric disorders and has advantages including noninvasiveness, lower cost, and ease of use compared with other imaging techniques, like functional magnetic resonance imaging. The verbal fluency task is the most common and well established task used to assess cognitive activation during near-infrared spectroscopy. Recent functional neuroimaging studies have shown that the orbitofrontal cortex and other brain regions, including the dorsolateral prefrontal cortex, may play important roles in the pathophysiology of obsessive-compulsive disorder (OCD). This study aimed to evaluate hemodynamic responses in the dorsolateral prefrontal cortex in patients with OCD using near-infrared spectroscopy during the verbal fluency task and to compare these with dorsolateral prefrontal cortex responses in healthy controls. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 2% |
Unknown | 42 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 23% |
Other | 3 | 7% |
Student > Ph. D. Student | 3 | 7% |
Student > Master | 3 | 7% |
Professor | 2 | 5% |
Other | 9 | 21% |
Unknown | 13 | 30% |
Readers by discipline | Count | As % |
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Psychology | 9 | 21% |
Medicine and Dentistry | 7 | 16% |
Neuroscience | 5 | 12% |
Agricultural and Biological Sciences | 2 | 5% |
Social Sciences | 1 | 2% |
Other | 1 | 2% |
Unknown | 18 | 42% |