| Title |
Obvious optic disc swelling in a patient with cryopyrin-associated periodic syndrome
|
|---|---|
| Published in |
Clinical Ophthalmology, August 2013
|
| DOI | 10.2147/opth.s49281 |
| Pubmed ID | |
| Authors |
Mariko Kawai, Tadanobu Yoshikawa, Ryuta Nishikomori, Toshio Heike, Kanji Takahashi |
| Abstract |
Cryopyrin-associated periodic syndrome (CAPS) is a group of rare hereditary autoinflammatory diseases caused by mutations of the NLRP3 gene, and leads to excessive production of the proinflammatory cytokine, interleukin-lβ. A 35-year-old male presented with recurrent symptoms of urticarial-like rash, periodic fever, arthralgia, headache, and eye redness. His best-corrected visual acuity was 1.0 OD and 0.9 OS. Slit-lamp examination showed conjunctival and episcleral injection in both eyes. Ophthalmoscopy revealed obvious bilateral optic disc swelling and retinal vascular sheathing around the optic discs. Spectral domain optical coherence tomography also showed obvious optic disc swelling. Steroid and nonsteroidal anti-inflammatory drugs did not improve these symptoms. Genetic testing detected a heterozygous mutation of c.907G>A. Thus, the patient was genetically confirmed with CAPS. Visual acuity did not decrease for 3 years, although the optic discs became white in color. CAPS should therefore be distinguished from other disorders when examining optic disc swelling and/or uveitis patients with urticarial-like rash and periodic fever. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 31% |
| Other | 3 | 23% |
| Student > Doctoral Student | 2 | 15% |
| Student > Ph. D. Student | 2 | 15% |
| Professor > Associate Professor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 1 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 54% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
| Agricultural and Biological Sciences | 1 | 8% |
| Engineering | 1 | 8% |
| Unknown | 2 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2013.
All research outputs
#17,438,425
of 25,584,565 outputs
Outputs from Clinical Ophthalmology
#1,780
of 3,687 outputs
Outputs of similar age
#133,568
of 210,451 outputs
Outputs of similar age from Clinical Ophthalmology
#44
of 95 outputs
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