↓ Skip to main content

Dove Medical Press

Article Metrics

Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats

Overview of attention for article published in International Journal of Nanomedicine, October 2013
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
57 Dimensions

Readers on

mendeley
56 Mendeley
Title
Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats
Published in
International Journal of Nanomedicine, October 2013
DOI 10.2147/ijn.s47174
Pubmed ID
Authors

Daoud Ali, Alarifi, Amin Al-Doaiss, Bahy A. Ali, Mukhtar Ahamed, Abdulaziz A. Al-Khedhairy

Abstract

Titanium dioxide (TiO₂) nanoparticles are among the top five nanoparticles used in consumer products, paints, and pharmaceutical preparations. Given that exposure to such nanoparticles is mainly via the skin and inhalation, the present study was conducted in male Wistar albino rats (Rattus norvegicus). Our aim was to investigate the effect of TiO₂ nanoparticles on hepatic tissue in an attempt to understand their toxicity and the potential effect of their therapeutic and diagnostic use. To investigate the effects of TiO₂ nanoparticles on liver tissue, 30 healthy male Wistar albino rats were exposed to TiO₂ nanoparticles at doses of 63 mg, 126 mg, and 252 mg per animal for 24 and 48 hours. Serum glutamate oxaloacetate transaminase and alkaline phosphatase activity was altered. Changes in hepatocytes can be summarized as hydropic degeneration, cloudy swelling, fatty degeneration, portal and lobular infiltration by chronic inflammatory cells, and congested dilated central veins. The histologic alterations observed might be an indication of hepatocyte injury due to the toxicity of TiO₂ nanoparticles, resulting in an inability to deal with accumulated residues from the metabolic and structural disturbances caused by these nanoparticles. The appearance of cytoplasmic degeneration and destruction of nuclei in hepatocytes suggests that TiO₂ nanoparticles interact with proteins and enzymes in hepatic tissue, interfering with antioxidant defense mechanisms and leading to generation of reactive oxygen species which, in turn, may induce stress in hepatocytes, promoting atrophy, apoptosis, and necrosis. More immunohistochemical and ultrastructural investigations are needed in relation to TiO₂ nanoparticles and their potential effects when used as therapeutic and diagnostic tools.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 20%
Researcher 10 18%
Student > Bachelor 8 14%
Student > Doctoral Student 6 11%
Student > Master 5 9%
Other 13 23%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 20%
Chemistry 9 16%
Medicine and Dentistry 6 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Biochemistry, Genetics and Molecular Biology 4 7%
Other 11 20%
Unknown 11 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2019.
All research outputs
#14,764,029
of 22,727,570 outputs
Outputs from International Journal of Nanomedicine
#1,847
of 3,800 outputs
Outputs of similar age
#122,885
of 207,109 outputs
Outputs of similar age from International Journal of Nanomedicine
#44
of 95 outputs
Altmetric has tracked 22,727,570 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,800 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,109 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.