| Title |
Shape-dependent antibacterial effects of non-cytotoxic gold nanoparticles
|
|---|---|
| Published in |
International Journal of Nanomedicine, March 2017
|
| DOI | 10.2147/ijn.s124442 |
| Pubmed ID | |
| Authors |
Jelle Penders, Michelle Stolzoff, Daniel J Hickey, Martin Andersson, Thomas J Webster |
| Abstract |
Gold nanoparticles (AuNPs) of various shapes (including spheres, stars and flowers), with similar dimensions, were synthesized and evaluated for their antibacterial effects toward Staphylococcus aureus, a bacterium responsible for numerous life-threatening infections worldwide. Optical growth curve measurements and Gompertz modeling showed significant AuNP shape- and concentration-dependent decreases in bacterial growth with increases in bacterial growth lag time. To evaluate prospective use in in vivo systems, the cytotoxicity of the same AuNPs was evaluated toward human dermal fibroblasts in vitro by 3-(4,5 dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) viability assays and confocal microscopy. No indication of any mammalian cell toxicity or morphological effects was found. Additionally, it was observed that the AuNPs were readily internalized in fibroblasts after 4 days of incubation. Most importantly, the results of the present study showed that gold nanoflowers in particular possessed the most promising non-cytotoxic mammalian cell behavior with the greatest shape-dependent antibacterial activity-promising properties for their future investigation in a wide range of anti-infection applications. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 20% |
| Student > Bachelor | 16 | 15% |
| Student > Master | 13 | 12% |
| Student > Doctoral Student | 11 | 10% |
| Researcher | 9 | 8% |
| Other | 8 | 8% |
| Unknown | 28 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 12% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 8% |
| Agricultural and Biological Sciences | 8 | 8% |
| Immunology and Microbiology | 6 | 6% |
| Other | 25 | 24% |
| Unknown | 34 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from International Journal of Nanomedicine
#3,598
of 4,122 outputs
Outputs of similar age
#285,015
of 324,443 outputs
Outputs of similar age from International Journal of Nanomedicine
#79
of 95 outputs
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